Endocrine Abstracts

A 35 year old woman presented with severe bone pain, body aches, progressive deformities of chest, skull and swelling of hands for two years. Past history included bilateral total hip replacement for fracture of neck of femur one year back. She was normotensive and normo-glycemic. Her dietary consumption of calcium and vitamin D and sun-exposure was adequate. Investigation revealed haemoglobin 5.4gram per deciliter. Serum calcium and serum iPTH levels were elevated at 3.6milim...

The Estrogen Receptor (ER) is a well-studied, ligand dependent transcription factor. We have analysed, by kinetic chromatin immunoprecipitation (ChIP) assays, the mechanisms by which the ER modulates the permissiveness and transcriptional activity of the PS2 gene. Sequential ChIP assays were used to define the cyclical association of approximately 50 different proteins to the pS2 promoter. Key results from these studies are (i) that unliganded and liganded ER direct cycling on...